环磷腺苷和环磷鸟苷衍生物对猫乳头肌收缩力的影响。
Effects of derivatives of cyclic amp and cyclic gmp on contraction force of cat papillary muscles.
作者信息
Wilkerson R D, Paddock R J, George W J
出版信息
Eur J Pharmacol. 1976 Mar;36(1):247-51. doi: 10.1016/0014-2999(76)90280-6.
Right ventricular kitten papillary muscles were incubated with dibutyryl adenosine 3',5'-monophosphate (dbcAMP) at varying concentrations as low as 1 X 10(-4)M. A positive inotropic effect was observed with all concentrations of dbcAMP. Concomitant administration of 5 X 10(-4)M monobutyryl guanosine 3',5'-monophosphate (mbcGMP) and 1-2 X 10(-4)M dbcAMP prevented the inotropic response observed when dbcAMP was used alone. When higher doses of dbcAMP were used (5 X 10(-4) M, 10 X 10(-4) M), there was no significant difference in the inotropic response seen between control tissues and papillary muscles pretreated with mbcGMP.
将右心室小猫乳头肌与浓度低至1×10⁻⁴M的不同浓度的二丁酰腺苷3',5'-单磷酸（dbcAMP）一起孵育。在所有浓度的dbcAMP下均观察到正性肌力作用。同时给予5×10⁻⁴M的单丁酰鸟苷3',5'-单磷酸（mbcGMP）和1 - 2×10⁻⁴M的dbcAMP可阻止单独使用dbcAMP时观察到的正性肌力反应。当使用更高剂量的dbcAMP（5×10⁻⁴M，10×10⁻⁴M）时，对照组织与用mbcGMP预处理的乳头肌之间观察到的正性肌力反应没有显著差异。
Zotero 插件