Kourilsky P, Jaulin C, Ley V
Unité de Biologie Moléculaire du Gène, U. 277 INSERM-U.A.C. 535 CNRS, Institut Pasteur, France.
Semin Cancer Biol. 1991 Oct;2(5):275-82.
We briefly survey recent basic progress on the structure and function of MHC molecules. We call attention on a number of remaining unanswered questions, and focus on a few points which we think might be of importance in immune surveillance against tumors mediated by MHC restricted T cells. In particular, we discuss the possible peptidic nature of certain tumor antigens. Following these lines, we mention a recent approach for the in vivo activation of specific CTL.
我们简要综述了近期关于主要组织相容性复合体（MHC）分子结构与功能的基础研究进展。我们提请注意一些尚未解答的问题，并聚焦于一些我们认为在由MHC限制性T细胞介导的肿瘤免疫监视中可能具有重要意义的要点。特别是，我们讨论了某些肿瘤抗原可能的肽性质。按照这些思路，我们提及了一种在体内激活特异性细胞毒性T淋巴细胞（CTL）的最新方法。
