Renoux G, Renoux M, Guillaumin J M
Dev Biol Stand. 1976;31:110-4.
The PMF fraction of B. melitensis creates a wasting disease in newborn mice (J. infect. Dis., 1973, 127, p. 139). Administered to adult mice, PMF induces a 4 to 8 g loss of weight in 20 g mice and more markedly in males than in females. Treatment with Levamisole (LMS) suppresses this difference in response to PMF and restores normal weight in 24 days. Diethyldithiocarbamate (DDC), another immunostimulant sulfur derivate, abolishes the emaciating effect of PMF. Furthermore, DDC is an anabolizing agent which increases the weight of normal or PMF-treacted mice above the mean level of normal untreated control mice.
布鲁氏菌的PMF组分可导致新生小鼠出现消耗性疾病（《传染病杂志》，1973年，第127卷，第139页）。将PMF施用于成年小鼠时，20克重的小鼠体重会减轻4至8克，且雄性小鼠比雌性小鼠更为明显。用左旋咪唑（LMS）进行治疗可抑制对PMF反应的这种差异，并在24天内使体重恢复正常。二乙基二硫代氨基甲酸盐（DDC），另一种免疫刺激硫衍生物，可消除PMF的消瘦作用。此外，DDC是一种同化剂，可使正常或经PMF处理的小鼠体重增加至高于正常未处理对照小鼠的平均水平。
