Gilligan D, Slevin N J
Department of Clinical Oncology and Radiotherapy, Christie Hospital, Manchester, UK.
Br J Radiol. 1991 Dec;64(768):1147-50. doi: 10.1259/0007-1285-64-768-1147.
Mucosal melanoma is rare and is traditionally treated by radical surgery. A retrospective survey was made of 28 cases of malignant mucosal melanoma of the nasal cavity and paranasal sinuses treated by definitive radiotherapy. Initial complete regression was observed in 22 out of 28 cases (79%). Absolute local control by radiotherapy alone was achieved in 17 out of 28 cases (61%) but follow-up was limited in many cases by early death due to metastatic disease; actuarial local disease-free survival was 49% at 3 years. The approach of radical radiotherapy for melanoma of this site can be justified on the basis of the local control achieved, low treatment morbidity in patients who are typically elderly and the propensity to disseminated disease. Doses of radiotherapy required to achieve local control need to be radical; the influence of dose per fraction is uncertain.
黏膜黑色素瘤较为罕见，传统上采用根治性手术治疗。对28例接受根治性放疗的鼻腔及鼻窦恶性黏膜黑色素瘤患者进行了回顾性调查。28例中有22例（79%）观察到初始完全缓解。28例中有17例（61%）仅通过放疗实现了绝对局部控制，但在许多病例中，随访因转移性疾病导致的早期死亡而受限；3年时精算局部无病生存率为49%。基于所实现的局部控制、在典型老年患者中较低的治疗发病率以及疾病播散倾向，对该部位黑色素瘤采用根治性放疗的方法是合理的。实现局部控制所需的放疗剂量需要达到根治性；每次分割剂量的影响尚不确定。
