Mocchegiani E, Fabris N, Travaglini P, Sartorio A, De Min C, Paolucci P
Immunol. ctr., Res. Dept. INRCA, Ancona, Italy.
Int J Neurosci. 1991 Jul;59(1-3):151-7. doi: 10.3109/00207459108985458.
Experimental and clinical evidences suggest that thymic endocrine function is modulated by the neuroendocrine network and in particular by growth hormone. The plasma of thymulin has been found reduced in congenital hypopituitarism and increased in acromegalic conditions when compared with the values observed in age-matched controls. In the present paper we have investigated in congenital GH-deficient children the effect of one year therapy with GH on the plasma level of thymulin, IGF-1 and plasma zinc; this last parameter has been checked because zinc is required for thymulin activity and modulates IGF-1 production. The basal thymulin and IGF-1 values are lower in GH deficient children than age-matched controls whereas zinc levels show a slight reduction. GH therapy induces a significant increment both of thymulin and IGF-1 levels and a slight increase of plasma zinc. A positive correlation has been found between zinc values and thymulin activity but not between GH and thymulin. Whether the recovery of thymulin production in GH deficient children by GH therapy is mediated by IGF-1 or by bioavailability of zinc ions remains to be established.
实验和临床证据表明，胸腺内分泌功能受神经内分泌网络调节，尤其是生长激素的调节。与年龄匹配的对照组相比，先天性垂体功能减退患者血浆胸腺素水平降低，肢端肥大症患者血浆胸腺素水平升高。在本文中，我们研究了先天性生长激素缺乏儿童接受一年生长激素治疗对血浆胸腺素、胰岛素样生长因子-1（IGF-1）水平及血浆锌的影响；检查了最后一个参数，因为锌是胸腺素活性所必需的，并且调节IGF-1的产生。生长激素缺乏儿童的基础胸腺素和IGF-1值低于年龄匹配的对照组，而锌水平略有降低。生长激素治疗可使胸腺素和IGF-1水平显著升高，血浆锌略有增加。已发现锌值与胸腺素活性之间呈正相关，但生长激素与胸腺素之间无相关性。生长激素治疗使生长激素缺乏儿童胸腺素产生的恢复是由IGF-1介导还是由锌离子的生物利用度介导，仍有待确定。
