丙泊酚用于破伤风镇静——它是一种肌肉松弛剂吗？

Sedation by propofol in tetanus--is it a muscular relaxant?

作者信息

Borgeat A, Dessibourg C, Rochani M, Suter P M

机构信息

Surgical Intensive Care Unit, University Hospital of Geneva, Switzerland.

出版信息

Intensive Care Med. 1991;17(7):427-9. doi: 10.1007/BF01720683.

DOI:10.1007/BF01720683

PMID:1774399

Abstract

We investigated the muscular relaxant properties of propofol in a 54 year-old-man with severe tetanus. Four consecutive boluses of propofol 50 mg i.v. were administered. Mean muscular activity recorded on an electromyography (EMG) decreased from 100 to 10-25 mV within 15 s after each bolus. EMG values were restored to prior levels 10 min after the last bolus. Maximum decrease of muscular activity was observed with propofol blood level between 2.90-3.20 micrograms.ml-1. Neuromuscular function recorded by means of evoked electromyography was not affected by propofol administration.

摘要

我们研究了丙泊酚对一名54岁重度破伤风男性患者的肌肉松弛特性。静脉注射了连续4次50毫克的丙泊酚推注剂量。每次推注后15秒内，通过肌电图（EMG）记录的平均肌肉活动从100毫伏降至10 - 25毫伏。最后一次推注后10分钟，EMG值恢复到先前水平。当丙泊酚血药浓度在2.90 - 3.20微克/毫升之间时，观察到肌肉活动的最大降幅。通过诱发肌电图记录的神经肌肉功能不受丙泊酚给药的影响。