Lacy J A
Nutr Clin Pract. 1991 Feb;6(1):18-20. doi: 10.1177/011542659100600118.
Toxic epidermal necrolysis is a rapidly progressive dermatologic condition associated with high mortality. Several factors have been implicated in the development of toxic epidermal necrolysis including drugs, vaccinations, infections, and neoplasia. Toxic epidermal necrolysis therapy has been compared with partial-thickness burn injury treatment. The absence of burned tissue can dampen fluid requirements and metabolic needs of toxic epidermal necrolysis in comparison to equivalent burn injury. In the following case report, a 69-year-old woman with multiple medical problems developed toxic epidermal necrolysis after treatment with metolazone and phenytoin. Her measured energy expenditure (3360 kcal) was considerably higher than previously reported caloric expenditure in toxic epidermal necrolysis patients (2500 kcal).
中毒性表皮坏死松解症是一种进展迅速的皮肤病，死亡率很高。中毒性表皮坏死松解症的发病涉及多种因素，包括药物、疫苗接种、感染和肿瘤。中毒性表皮坏死松解症的治疗方法已与浅二度烧伤的治疗方法进行了比较。与同等程度的烧伤相比，没有烧伤组织会降低中毒性表皮坏死松解症的液体需求量和代谢需求。在以下病例报告中，一名患有多种疾病的69岁女性在使用美托拉宗和苯妥英治疗后发生了中毒性表皮坏死松解症。她测得的能量消耗（3360千卡）明显高于先前报道的中毒性表皮坏死松解症患者的热量消耗（2500千卡）。
