Gellert R, Billip-Tomecka Z, Hijaz H, Bogdańska-Straszyńska B, Małecka B, Siciński A
Department of Medicine, Warsaw Medical School, Poland.
Nephrol Dial Transplant. 1991;6 Suppl 3:10-3.
Haemodialysis (HD) should affect the erythrocytes, which constitute more than 99% of blood cells. The aim of this study was to reinvestigate the intradialytic changes in erythrocyte water content (MCV). MCV was measured during 81 HD (47 uncomplicated, 34 with hypotension), and 16 isolated ultrafiltrations (UF) performed in stable, haemodialysed adults (12 males and 8 females). The MCV following uncomplicated HD (n = 32) did not differ from the predialysis value. Significant MCV increase accompanied the HD initiation (4.9 +/- 9.0 fl, P less than 0.001), UF (2.99 +/- 1.49 fl, P less than 0.001) and hypotension (1.8 +/- 3.1 fl, P less than 0.01). This was independent of sodium and potassium within the cells and plasma. Erythrocyte oedema occurred in situations known to accompany both bioincompatibility reactions and blood volume decrease. Intradialytic MCV increase may reflect a response to these events, possibly hormonal, and needs further investigation.
血液透析（HD）会影响红细胞，红细胞在血细胞中所占比例超过99%。本研究的目的是再次研究透析过程中红细胞含水量（MCV）的变化。对稳定的血液透析成年患者（12名男性和8名女性）进行了81次血液透析（47次无并发症，34次伴有低血压）和16次单独超滤（UF），并在透析过程中测量了MCV。无并发症的血液透析（n = 32）后的MCV与透析前值无差异。血液透析开始时（4.9 +/- 9.0 fl，P < 0.001）、超滤时（2.99 +/- 1.49 fl，P < 0.001）和低血压时（1.8 +/- 3.1 fl，P < 0.01），MCV均显著增加。这与细胞内和血浆中的钠和钾无关。红细胞水肿发生在已知伴有生物不相容反应和血容量减少的情况下。透析过程中MCV增加可能反映了对这些事件的反应，可能是激素反应，需要进一步研究。
