Baurmeister U, Vienken J, Grassmann A
Institute for Medical Membrane Application, Akzo Fibers AG, Wuppertal, Germany.
Nephrol Dial Transplant. 1991;6 Suppl 3:17-21.
Development of new biocompatible membranes for clinical application needs the expertise of various specialists, chemists, chemical engineers, and clinicians. As the biocompatibility of a membrane cannot be considered in terms of a single biochemical pathway, due to the interrelation between the complement, coagulation, and inflammatory systems, it is difficult to achieve optimal results with one single polymer. A compromise between different approaches has therefore to be found. Membrane development also needs sophisticated test systems, which simulate the clinical situation as closely as possible. Adequate results are achieved with the 'ex vivo' model, which represents open-loop haemodialysis. The ex vivo model gives good results which are close to those from clinical experiments.
开发用于临床应用的新型生物相容性膜需要各类专家的专业知识，包括化学家、化学工程师和临床医生。由于补体、凝血和炎症系统之间存在相互关系，不能仅从单一生化途径来考虑膜的生物相容性，因此仅使用一种聚合物很难获得最佳效果。所以必须在不同方法之间找到折衷方案。膜的开发还需要精密的测试系统，该系统要尽可能逼真地模拟临床情况。“离体”模型（即代表开放式血液透析）能取得足够好的结果。离体模型给出的良好结果与临床实验结果相近。
