Frussa-Filho R, Palermo-Neto J
Department of Pharmacology, Escola Paulista de Medicina, Marília, São Paulo, Brazil.
Physiol Behav. 1991 Oct;50(4):825-30. doi: 10.1016/0031-9384(91)90024-i.
The effects of single and long-term droperidol administration on rat open-field and apomorphine-induced stereotyped behavior were studied. A single dose of droperidol decreased dose dependently not only locomotion and rearing frequencies in the open-field but also the apomorphine effects. Long-term droperidol administration induced significant tolerance to all parameters of activity recorded in the open-field. Unlike other dopamine blockers, droperidol withdrawn from long-term droperidol administration wasn't able to increase rats' open-field parameters significantly. However, like other dopamine blockers, droperidol withdrawn produced an augmented responsiveness to apomorphine-induced stereotyped behavior. These results suggest that the supersensitivity of central dopamine receptors developed after droperidol treatment may have peculiar characteristics.
研究了单次及长期给予氟哌利多对大鼠旷场行为和阿扑吗啡诱导的刻板行为的影响。单次给予氟哌利多不仅剂量依赖性地降低了旷场中的运动和直立频率，还降低了阿扑吗啡的作用。长期给予氟哌利多会导致对旷场中记录的所有活动参数产生显著耐受性。与其他多巴胺阻滞剂不同，长期给予氟哌利多后停药，氟哌利多并不能显著提高大鼠的旷场参数。然而，与其他多巴胺阻滞剂一样，停药后的氟哌利多会使大鼠对阿扑吗啡诱导的刻板行为反应增强。这些结果表明，氟哌利多治疗后中枢多巴胺受体的超敏反应可能具有特殊特征。
