Goraish I A, Abdelsalam E B, Tartour G
Department of Pathology, Faculty of Veterinary Science, University of Khartoum, Sudan.
Rev Elev Med Vet Pays Trop. 1991;44(1):69-73.
Goats previously infected with 100 viable Fasciola gigantica metacercariae and treated with rafoxanide (Ranide, 7.5 mg/kg) at week 4 were not protected against subsequent homologous challenge with 250 metacercariae administered two weeks later. Reinfection resulted in more severe hepatic lesions and a higher percentage of flukes recovered as compared with primarily infected controls. However, the size of flukes originating from the second (challenge) infection was considerably reduced. The plasma enzyme activity of aspartate amino-transferase (AST), glutamate dehydrogenase (GD) and sorbitol dehydrogenase (SD) increased to a similar extent with primary and challenge infections. However, the plasma antibody response to F. gigantica was less pronounced in reinfected goats.
先前感染了100条活的巨片形吸虫囊蚴并在第4周用硝碘酚腈（Ranide，7.5毫克/千克）治疗的山羊，在两周后接受250条囊蚴的后续同源攻击时未受到保护。与初次感染的对照组相比，再次感染导致更严重的肝脏病变和更高的吸虫回收率。然而，源自第二次（攻击）感染的吸虫大小显著减小。初次感染和再次感染时，天冬氨酸转氨酶（AST）、谷氨酸脱氢酶（GD）和山梨醇脱氢酶（SD）的血浆酶活性升高程度相似。然而，再次感染的山羊对巨片形吸虫的血浆抗体反应不太明显。
