[Prediction of late restenosis using early treadmill exercise testing after PTCA].

The purpose of this study was to evaluate the capability of treadmill exercise testing early after percutaneous transluminal coronary angioplasty (PTCA) for prediction of restenosis during the follow-up period. Subjects were comprised of 30 patients with single vessel disease, in whom angiographic success immediately after PTCA was obtained. Follow-up coronary angiography at a mean of 3.5 months after initial PTCA demonstrated restenosis in 15 patients. Treadmill exercise testing was conducted before PTCA (pre-EX), at a mean of 11 days after PTCA (early-EX), and at a mean of 3.2 months after PTCA (late-EX). The degree of residual stenosis immediately after PTCA measured using videodensitometry was similar in both the groups with and without restenosis. In the non-restenosis group, Functional aerobic impairment (FAI), myocardial aerobic impairment (MAI), and heart rate impairment (HRI) measured in the early-EX period improved significantly compared to that in the pre-EX period (p less than 0.05, p less than 0.01, and p less than 0.05, respectively). There were no significant changes in the restenosis group. Using exercise parameters before and soon after PTCA, a discriminant analysis was made between these groups. The formula was defined as follows; Z = 0.0178 x (FAI of pre-EX) +0.0543x (FAI of early-EX) +0.0513x (MAI of pre-EX) -0.1056x (MAI of early-EX) -0.3135. Under this formula, 14 of the 17 patients with Z less than 0 had restenosis during the follow-up period.(ABSTRACT TRUNCATED AT 250 WORDS)