接受高效抗逆转录病毒治疗的HIV-1感染儿童的血清瘦素浓度与脂肪重新分布

Serum leptin concentrations and fat redistribution in HIV-1-infected children on highly active antiretroviral therapy.

作者信息

Dzwonek A B, Novelli V, Schwenk A

机构信息

Infectious Diseases and Microbiology Unit, University College London Institute of Child Health, and Clinical Infectious Diseases Unit, Great Ormond Street Children's Hospital NHS Trust, London, UK.

出版信息

HIV Med. 2007 Oct;8(7):433-8. doi: 10.1111/j.1468-1293.2007.00490.x.

DOI:10.1111/j.1468-1293.2007.00490.x

PMID:17760735

Abstract

OBJECTIVES

HIV-related lipodystrophy is a syndrome of adipose tissue redistribution, dyslipidaemia and insulin resistance. Combination antiretroviral therapy (CART) is a key risk factor. We hypothesized that fat redistribution in HIV-infected children is related to altered endocrine function of adipose tissue, namely leptin secretion.

METHODS

Serum leptin and fat redistribution were measured in 104 HIV-infected children in a prospective observational study from 2003 to 2004. Fat redistribution was defined by clinical observation. Body fatness was estimated using body mass index and four skinfold measurements. Serum leptin was determined using an enzyme-linked immunosorbent assay (Quantikine; R&D Systems, Abingdon, UK). Linear analogue models were used to adjust the leptin concentration for body fatness.

RESULTS

There was no significant difference in serum leptin among children treated with protease inhibitors (PIs), children on non-PI CART and children not treated with CART (P>0.05). When leptin concentrations were adjusted for body fatness, there was again no difference among PI-treated, non-PI-treated and untreated children. Categorization of CART exposure as never, current or past did not change these results.

CONCLUSIONS

There is no evidence that leptin plays any role in lipodystrophy other than reflecting body fatness.

摘要

目的

与人类免疫缺陷病毒（HIV）相关的脂肪代谢障碍是一种脂肪组织重新分布、血脂异常和胰岛素抵抗的综合征。联合抗逆转录病毒疗法（CART）是一个关键危险因素。我们推测，HIV感染儿童的脂肪重新分布与脂肪组织内分泌功能改变有关，即瘦素分泌。

方法

在2003年至2004年的一项前瞻性观察研究中，对104名HIV感染儿童进行了血清瘦素和脂肪重新分布的测量。通过临床观察来定义脂肪重新分布。使用体重指数和四处皮褶厚度测量来估计体脂情况。使用酶联免疫吸附测定法（Quantikine；R&D Systems，英国阿宾顿）测定血清瘦素。使用线性模拟模型对体脂情况下的瘦素浓度进行校正。