接受蛋白酶抑制剂治疗的儿童中存在人类免疫缺陷病毒相关脂肪代谢障碍综合征的证据。
Evidence of human immunodeficiency virus-associated lipodystrophy syndrome in children treated with protease inhibitors.
作者信息
Bockhorst James L, Ksseiry Iyad, Toye Maripat, Chipkin Stuart R, Stechenberg Barbara W, Fisher Donna J, Allen Holley F
机构信息
Department of Medicine, Baystate Medical Center, 759 Chestnut Street, Springfield, MA 01199, USA.
出版信息
Pediatr Infect Dis J. 2003 May;22(5):463-5.
We conducted a prospective evaluation for evidence of the HIV-associated lipodystrophy syndrome of 26 children infected with HIV-1. Six children had evidence of body fat redistribution. Nine children showed laboratory evidence of insulin resistance. All children with body fat distribution or insulin resistance had been treated with protease inhibitors. Children treated with protease inhibitors had higher total cholesterol, higher low density lipoprotein-cholesterol and higher triglycerides than untreated children.
我们对26名感染HIV-1的儿童进行了前瞻性评估，以寻找与HIV相关的脂肪代谢障碍综合征的证据。6名儿童有体脂重新分布的证据。9名儿童有胰岛素抵抗的实验室证据。所有有体脂分布异常或胰岛素抵抗的儿童均接受过蛋白酶抑制剂治疗。接受蛋白酶抑制剂治疗的儿童比未接受治疗的儿童总胆固醇、低密度脂蛋白胆固醇和甘油三酯水平更高。
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