Ruel Guillaume, Pomerleau Sonia, Couture Patrick, Lemieux Simone, Lamarche Benoît, Couillard Charles
Department of Food Science and Nutrition, Laval University, 2440 Boulevard Hochelaga, Québec, Canada G1K 7P4.
Br J Nutr. 2008 Feb;99(2):352-9. doi: 10.1017/S0007114507811986. Epub 2007 Aug 29.
Elevated circulating concentrations of oxidized LDL (OxLDL) and cell adhesion molecules are considered to be relevant markers of oxidative stress and endothelial activation which are implicated in the development of CVD. On the other hand, it has been suggested that dietary flavonoid consumption may be cardioprotective through possible favourable impacts on LDL particle oxidation and endothelial activation. The present study was undertaken to determine the effect of the daily consumption of low-calorie cranberry juice cocktail on plasma OxLDL, intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and E-selectin concentrations in men. Thirty men (mean age 51 (sd 10) years) were recruited and asked to consume increasing daily doses of cranberry juice cocktail (125, 250 and 500 ml/d) over three successive periods of 4 weeks. Plasma OxLDL and adhesion molecule concentrations were measured by ELISA before and after each phase. We noted a significant decrease in plasma OxLDL concentrations following the intervention (P < 0.0001). We also found that plasma ICAM-1 (P < 0.0001) and VCAM-1 (P < 0.05) concentrations decreased significantly during the course of the study. In summary, the present results show that daily cranberry juice cocktail consumption is associated with decreases in plasma OxLDL, ICAM-1 and VCAM-1 concentrations in men.
循环氧化低密度脂蛋白（OxLDL）和细胞粘附分子浓度升高被认为是氧化应激和内皮激活的相关标志物，与心血管疾病（CVD）的发生有关。另一方面，有人提出，食用膳食类黄酮可能通过对低密度脂蛋白颗粒氧化和内皮激活产生可能的有利影响而具有心脏保护作用。本研究旨在确定每日饮用低热量蔓越莓汁鸡尾酒对男性血浆OxLDL、细胞间粘附分子-1（ICAM-1）、血管细胞粘附分子-1（VCAM-1）和E-选择素浓度的影响。招募了30名男性（平均年龄51（标准差10）岁），并要求他们在连续三个为期4周的时间段内，每天饮用递增剂量的蔓越莓汁鸡尾酒（125、250和500毫升/天）。在每个阶段前后，通过酶联免疫吸附测定法（ELISA）测量血浆OxLDL和粘附分子浓度。我们注意到干预后血浆OxLDL浓度显著降低（P < 0.0001）。我们还发现，在研究过程中，血浆ICAM-1（P < 0.0001）和VCAM-1（P < 0.05）浓度显著降低。总之，目前的结果表明，男性每日饮用蔓越莓汁鸡尾酒与血浆OxLDL、ICAM-1和VCAM-1浓度降低有关。
