Aghdassi Elaheh, Wendland Barbara E, Stapleton Melanie, Raman Maitreyi, Allard Johane P
The University Health Network, Toronto, Canada.
J Am Diet Assoc. 2007 Sep;107(9):1575-80. doi: 10.1016/j.jada.2007.06.011.
Crohn's disease is frequently associated with nutritional deficiencies, often a result of disease activity and poor oral intake. This study investigated the adequacy of dietary intake, based on the Canadian Dietary Reference Intake, in ambulatory patients with Crohn's disease and a normal body mass index (BMI; calculated as kg/m(2)). This was a cross-sectional study of 74 patients with mean age of 35.7+/-1.4 years and BMI of 23.05+/-0.45. All patients completed a 7-day food record and a diary for the Crohn's Disease Activity Index. Mean Crohn's Disease Activity Index was 138.99+/-11.38. Energy and protein intakes were within the recommended levels of intake, but total carbohydrates, fat, and saturated fat intake exceeded the recommended levels of <55%, <35%, and <10% in 39.2%, 27%, and 59.5% of the patients, respectively. Micronutrient intakes were suboptimal most notably for folate, vitamins C, E, and calcium. There were no substantial differences between patients with active and inactive disease in terms of failure to meet the Dietary Reference Intake. In conclusion, in this population sample, a large number of ambulatory patients with Crohn's disease have suboptimal dietary patterns despite a normal BMI and inactive disease. Dietary counseling and supplementation may be warranted in this patient population.
克罗恩病常伴有营养缺乏,这通常是疾病活动和口服摄入量低的结果。本研究基于加拿大膳食参考摄入量,调查了体重指数(BMI;计算方法为千克/米²)正常的克罗恩病门诊患者的饮食摄入量是否充足。这是一项横断面研究,共纳入74例患者,平均年龄为35.7±1.4岁,BMI为23.05±0.45。所有患者均完成了一份7天的饮食记录以及一份克罗恩病活动指数日记。克罗恩病活动指数的平均值为138.99±11.38。能量和蛋白质摄入量在推荐摄入水平范围内,但分别有39.2%、27%和59.5%的患者,其总碳水化合物、脂肪和饱和脂肪摄入量超过了推荐水平(分别为<55%、<35%和<10%)。微量营养素摄入量欠佳,最明显的是叶酸、维生素C、维生素E和钙。在未达到膳食参考摄入量方面,疾病活动期和非活动期患者之间没有实质性差异。总之,在这个人群样本中,尽管BMI正常且疾病处于非活动期,但大量克罗恩病门诊患者的饮食模式欠佳。对这一患者群体可能有必要进行饮食咨询和补充。