Ishii Genki, Suzuki Akihito, Oshino Shingo, Shiraishi Hiroaki, Matsumoto Yoshihiko, Otani Koichi, Goto Kaoru
Department of Psychiatry, Yamagata University School of Medicine, 2-2-2 Iidanishi, Yamagata-city, Yamagata 990-9585, Japan.
Eur Psychiatry. 2007 Oct;22(7):462-5. doi: 10.1016/j.eurpsy.2007.05.005. Epub 2007 Aug 30.
Catechol-O-methyltransferase (COMT) is one of the major enzymes for the degradation of catecholamines. It has been suggested that catecholaminergic neurotransmission is involved in characterization of personality. Previous studies on the association between the COMT Val158Met polymorphism and personality traits in healthy subjects have produced inconsistent results. Therefore, the relationship between this polymorphism and personality was re-examined in 478 Japanese healthy volunteers. Personality traits were assessed by the Temperament and Character Inventory (TCI), and the COMT genotypes were determined by a PCR-RFLP method. In total, there were no significant differences among the Val/Val, Val/Met, and Met/Met genotypes in seven TCI dimension scores. Similarly, no significant relationship was found between the COMT genotypes and the TCI dimensions when males and females were analyzed separately. The present study thus suggests that the COMT Val158Met polymorphism is not associated with personality traits in Japanese healthy subjects.
儿茶酚-O-甲基转移酶（COMT）是儿茶酚胺降解的主要酶之一。有人提出儿茶酚胺能神经传递与人格特征有关。先前关于健康受试者中COMT Val158Met多态性与人格特质之间关联的研究结果并不一致。因此，在478名日本健康志愿者中重新审视了这种多态性与人格之间的关系。通过气质和性格量表（TCI）评估人格特质，并通过PCR-RFLP方法确定COMT基因型。总体而言，在七个TCI维度得分中，Val/Val、Val/Met和Met/Met基因型之间没有显著差异。同样，单独分析男性和女性时，未发现COMT基因型与TCI维度之间存在显著关系。因此，本研究表明COMT Val158Met多态性与日本健康受试者的人格特质无关。
