儿茶酚-O-甲基转移酶（COMT）基因在人格和相关精神病理障碍中的作用。
The role of the catechol-O-methyltransferase (COMT) gene in personality and related psychopathological disorders.
机构信息
Department of Psychology, University of Bonn, Germany.
出版信息
CNS Neurol Disord Drug Targets. 2012 May;11(3):236-50. doi: 10.2174/187152712800672382.
Abstract
This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
摘要
这篇综述简要介绍了最具影响力的几种基于生物学的人类人格理论。文中将介绍艾森克、格雷和麦克诺顿、克隆内格和彭塞普的人格概念，并总结人格遗传性的关键证据。在此背景下，文中将概述在上述几种基于生物学的人格理论框架下，进行的大量 COMT 基因关联研究（重点介绍 COMT Val158Met 多态性）。根据健康焦虑行为和相关精神病理学行为之间存在连续体模型的理论，文中将讨论 COMT 基因在焦虑障碍中的作用。最后展望了新的研究策略，如遗传影像学和表观遗传学，以更好地理解人类人格。
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