Seveau Stéphanie, Pizarro-Cerda Javier, Cossart Pascale
Departments of Microbiology and Internal Medicine, Center for Microbial Interface Biology, Ohio State University, Columbus, OH 43210, USA.
Microbes Infect. 2007 Aug;9(10):1167-75. doi: 10.1016/j.micinf.2007.05.004. Epub 2007 May 7.
The facultative intracellular bacterial pathogen Listeria monocytogenes has evolved multiple strategies to invade a large panel of mammalian cells. Host cell invasion is critical for several stages of listeriosis pathology such as the initial crossing of the host intestinal barrier and the successive colonization of diverse target organs including the placenta. In this review, we address the main molecular mechanisms known to be used by L. monocytogenes during invasion of nonphagocytic cells and host tissues.
兼性胞内细菌病原体单核细胞增生李斯特菌已进化出多种策略来侵入大量哺乳动物细胞。宿主细胞入侵对于李斯特菌病病理的几个阶段至关重要，例如宿主肠道屏障的初始穿越以及包括胎盘在内的各种靶器官的连续定植。在本综述中，我们阐述了已知单核细胞增生李斯特菌在侵入非吞噬细胞和宿主组织过程中使用的主要分子机制。
