Uzunismail Adnan, Perk Cem, Findik Hasan, Beyhan Gökhan, Dincler Mahmut
Department of Plastic and Reconstructive Surgery, Haydarpasa Numune Teaching and Research Hospital, Istanbul, Turkey.
J Plast Reconstr Aesthet Surg. 2008 Oct;61(10):1199-204. doi: 10.1016/j.bjps.2007.06.030. Epub 2007 Aug 30.
The effects of a fascial tissue interface on silicone implant capsule formation were studied in a rabbit model. In two experimental groups, the thoracodorsal fascia was harvested either as a free graft (Group Ia) or as a fascial flap (Group Ib), then wrapped around silicone implants prior to subcutaneous placement. In each instance the fascia was configured to form a biological interface between the implant and surrounding soft tissue. The resulting capsules were macroscopically and histologically compared to a control group (Group II) of unwrapped silicone implants which were inserted subcutaneously. The cellular response to textured and smooth surfaces on opposing sides of each implant was also separately investigated in both study groups. Statistical analysis was performed using a Student's t-test. The capsules formed in each experimental group were observed to be thinner and less cellular when compared to the unwrapped control group (P<0.05), while no demonstrable differences between fascial flap and free graft subgroups were found (P>0.05). Furthermore, less cellularity and reduced capsule thickness were observed in the textured implant capsule surfaces in both fascial flap and free graft groups when compared to smooth implant capsule surfaces (P<0.05). Our preliminary study findings using a fascial tissue interface, either as a flap or a free graft, reveal cellular architectural characteristics of the resulting capsule that may be significant in minimising capsular contraction around silicone implants.
在兔模型中研究了筋膜组织界面对硅胶植入物包膜形成的影响。在两个实验组中，背阔肌筋膜分别作为游离移植片（Ia组）或筋膜瓣（Ib组）获取，然后在皮下植入硅胶植入物之前将其包裹在植入物周围。在每种情况下，筋膜被构造成在植入物和周围软组织之间形成生物界面。将所得的包膜与皮下植入的未包裹硅胶植入物的对照组（II组）进行宏观和组织学比较。在两个研究组中还分别研究了每个植入物相对两侧的有纹理表面和平滑表面的细胞反应。使用学生t检验进行统计分析。与未包裹的对照组相比，每个实验组中形成的包膜更薄且细胞更少（P<0.05），而筋膜瓣和游离移植片子组之间未发现明显差异（P>0.05）。此外，与光滑植入物包膜表面相比，在筋膜瓣和游离移植片组的有纹理植入物包膜表面观察到细胞更少且包膜厚度减小（P<0.05）。我们使用筋膜组织界面（无论是作为瓣还是游离移植片）的初步研究结果揭示了所得包膜的细胞结构特征，这对于最小化硅胶植入物周围的包膜挛缩可能具有重要意义。
