Fiúza Ulla-Maj, Arias Alfonso Martinez
Department of Genetics, University of Cambridge, Cambridge CB2 3EH, UK.
J Endocrinol. 2007 Sep;194(3):459-74. doi: 10.1677/JOE-07-0242.
Notch signalling is a cell-cell communication process, which allows the establishment of patterns of gene expression and differentiation, regulates binary cell fate choice and the maintenance of stem cell populations. So far, the data published has elucidated the main players in the Notch signalling pathway. However, its regulatory mechanisms are exhibiting an increasing complexity which could account for the multitude of roles it has during development and in adult organisms. In this review, we will describe the multiple roles of Notch and how various factors can regulate Notch signalling.
Notch信号传导是一种细胞间通讯过程，它能够建立基因表达和分化模式，调节细胞命运的二元选择以及干细胞群体的维持。到目前为止，已发表的数据阐明了Notch信号通路中的主要参与者。然而，其调控机制正呈现出越来越高的复杂性，这可能解释了它在发育过程和成年生物体中所具有的多种作用。在这篇综述中，我们将描述Notch的多种作用以及各种因素如何调节Notch信号传导。
