基于新的纳米剂量学的混合中子和伽马射线辐照细胞存活模型的实验验证

Experimental validation of the new nanodosimetry-based cell survival model for mixed neutron and gamma-ray irradiation.

作者信息

Wang C-K Chris, Zhang Xin, Gifford Ian, Burgett Eric, Adams Vince, Al-Sheikhly Mohamad

机构信息

Nuclear/Radiological Engineering/Medical Physics Program Neely Research Center, Georgia Institute of Technology, 900 Atlantic Drive, Atlanta, GA 30332-0425, USA.

出版信息

Phys Med Biol. 2007 Sep 7;52(17):N367-74. doi: 10.1088/0031-9155/52/17/N01. Epub 2007 Aug 7.

DOI:10.1088/0031-9155/52/17/N01

PMID:17762072

Abstract

The new nanodosimetry-based linear-quadratic (LQ) formula has been reviewed for mixed-LET irradiation. V-79 Chinese hamster cells have been irradiated with a mixed-LET field of fission neutrons and gamma rays at the University of Maryland Training Reactor (MUTR). The results show that the experimental survival curve agrees well with that predicted by the new nanodosimetry-based LQ model. The experimental study described in this note, therefore, serves as a validation for the new model to be used for mixed-LET radiotherapies, e.g. 252Cf brachytherapy.

摘要

基于新的纳米剂量学的线性二次（LQ）公式已针对混合传能线密度（LET）照射进行了评估。在马里兰大学培训反应堆（MUTR）中，V - 79中国仓鼠细胞已受到裂变中子和伽马射线的混合LET场照射。结果表明，实验存活曲线与基于新的纳米剂量学的LQ模型预测的曲线吻合良好。因此，本说明中描述的实验研究为该新模型用于混合LET放射治疗（例如252Cf近距离放射治疗）提供了验证。