Higgins P D, DeLuca P M, Pearson D W, Gould M N
Radiat Res. 1983 Jul;95(1):45-56.
A unique tandem source irradiation facility, composed of an intense d-T neutron source and a 60Co teletherapy unit, was used to investigate biological responses for different neutron/photon configurations. V79 Chinese hamster cells, attached as monolayers in log-phase growth, were irradiated at 37 degrees C by either 14.8-MeV neutrons, 60Co, or a mixture of 40% neutrons and 60% photons in simultaneous or sequential application. Measurements of cell survival indicate an increased effectiveness in cell killing for simultaneously administered neutrons and photons compared to that measured or predicted for sequentially applied beam modalities. An understanding of the magnitude of these interactive effects is important both for calculating accurate effective doses for neutron radiotherapy of deep-seated tumors, for which the photon component is appreciable, and for determination of environmental hazards to people occupationally exposed to mixtures of photons and neutrons.
一个由强流氘 - 氚中子源和钴 - 60远距离治疗装置组成的独特串联源辐照设施，被用于研究不同中子/光子配置下的生物反应。处于对数生长期的V79中国仓鼠单层贴壁细胞，在37摄氏度下接受14.8兆电子伏中子、钴 - 60或40%中子与60%光子的混合物同时或相继照射。细胞存活测量结果表明，与相继照射模式相比，同时给予中子和光子时细胞杀伤效果增强。了解这些相互作用效应的大小，对于计算深部肿瘤中子放射治疗的准确有效剂量（其中光子成分相当可观）以及确定职业暴露于光子和中子混合物环境中的人员所面临的环境危害都很重要。
