Ozgen Ilker Tolga, Dagdemir Ayhan, Elli Murat, Saraymen Recep, Pinarli Faruk Guclu, Fisgin Tunc, Albayrak Davut, Acar Sabri
Divisionsof Pediatric Oncology, Ondokuz Mayis University, Medical Faculty, Samsun, Turkey.
J Pediatr Hematol Oncol. 2007 Aug;29(8):519-22. doi: 10.1097/MPH.0b013e3180f61b3a.
Selenium (Se) is a trace element contributing to the structure of antioxidant system that saves cells from reactive oxygen species. Low serum Se levels have been reported in pediatric and adult patients with cancers. On the other hand, hair Se levels, predicting the long-term body Se status, have been reported in only adult patients with cancer. The aim of the study was to investigate the hair Se status in children with newly diagnosed lymphoid malignancies and the relation between malnutrition and Se deficiency. Thirty patients with leukemia (n=17) and lymphoma (n=13), and 25 healthy controls were enrolled to the study. Se was determined with atomic absorption spectrophotometrical method. Hair Se levels of the patients were significantly lower than those of control group [666.96+/-341.46 ng/g vs. 1019.22+/-371.83 ng/g (P<0.001)]. Children with lymphoma had lower Se than the children with acute lymphoblastic leukemia but not statistically significant [547.03+/-283.67 ng/g vs. 758.67+/-361.05 ng/g (P>0.05)]. Malnourished patients (11/30) had lower hair Se levels (483.51+/-235.55 ng/g) than those of the controls (P=0.036), whereas the Se levels of the patients who had no malnutrition (773.17+/-352.92 ng/g) were also lower than those of the controls but not statistically significant (P=0.053). There was no correlation between age, sex, and the hair Se levels. In this study, we found that hair Se levels of the children with leukemia and lymphoma, especially those of malnourished patients, were lower than those of controls. Additional studies are needed to determinate whether low levels of hair Se may play a role in carcinogenesis.
硒（Se）是一种微量元素，有助于构建抗氧化系统，使细胞免受活性氧的侵害。儿科和成年癌症患者中均有血清硒水平较低的报道。另一方面，仅在成年癌症患者中报道过可预测长期身体硒状态的头发硒水平。本研究的目的是调查新诊断的淋巴系统恶性肿瘤患儿的头发硒状态以及营养不良与硒缺乏之间的关系。30例白血病（n = 17）和淋巴瘤（n = 13）患者以及25名健康对照者纳入本研究。采用原子吸收分光光度法测定硒。患者的头发硒水平显著低于对照组[666.96±341.46 ng/g vs. 1019.22±371.83 ng/g（P<0.001）]。淋巴瘤患儿的硒水平低于急性淋巴细胞白血病患儿，但差异无统计学意义[547.03±283.67 ng/g vs. 758.67±361.05 ng/g（P>0.05）]。营养不良的患者（11/30）头发硒水平（483.51±235.55 ng/g）低于对照组（P = 0.036），而无营养不良的患者硒水平（773.17±352.92 ng/g）也低于对照组，但差异无统计学意义（P = 0.053）。年龄、性别与头发硒水平之间无相关性。在本研究中，我们发现白血病和淋巴瘤患儿，尤其是营养不良患者的头发硒水平低于对照组。需要进一步研究以确定低水平的头发硒是否可能在致癌过程中起作用。
