Rodriguez Clemencia, Weinstein Philip, Cook Angus, Devine Brian, Van Buynder Paul
School of Population Health, The University of Western Australia, Perth, Western Australia, Australia.
J Toxicol Environ Health A. 2007 Oct;70(19):1654-63. doi: 10.1080/15287390701434828.
The city of Perth in Western Australia is facing a future of compromised water supplies. In recent years, this urban region has been experiencing rapid population growth, coupled with drying climate, which has exacerbated water shortages. As part of the government strategy to secure water sustainability and to address an agenda focused on all elements of the water cycle, a target of 20% reuse of treated wastewater by 2012 was established. This includes a feasibility review of managed aquifer recharge for indirect potable reuse. A characterization of contaminants in wastewater after treatment and an assessment of the health implications are necessary to reassure both regulators and the public. To date, the commonly used approach involves a comparison of measured contaminant concentrations with the established drinking-water standards or other toxicological guidelines for the protection of human health. However, guidelines and standards have not been established for many contaminants in recycled water (unregulated chemicals). This article presents a three-tiered approach for the preliminary health risk assessment of chemicals in order to determine key contaminants that need to be monitored and managed. The proposed benchmark values for the calculation of risk quotients are health based, systematically defined, scientifically defensible, easy to apply, and clear to interpret. The proposed methodology is based on the derivation of health-based levels for unregulated contaminants with toxicity information and a "threshold of toxicological concern" for unregulated contaminants without toxicity data. The application of this approach will help policymakers set guidelines regarding unregulated chemicals in recycled water.
澳大利亚西部的珀斯市正面临着供水受影响的未来。近年来,这个城市地区人口快速增长,加上气候干旱,加剧了水资源短缺。作为政府确保水可持续性战略的一部分,以及应对围绕水循环所有要素议程的一部分,设定了到2012年将处理后的废水回用率提高到20%的目标。这包括对用于间接饮用水回用的管理含水层补给进行可行性审查。为了让监管机构和公众放心,有必要对处理后废水中的污染物进行特征描述,并评估其对健康的影响。迄今为止,常用的方法是将测得的污染物浓度与既定的饮用水标准或其他保护人类健康的毒理学指南进行比较。然而,对于再生水中的许多污染物(未受监管的化学品)尚未制定指南和标准。本文提出了一种用于化学品初步健康风险评估的三层方法,以确定需要监测和管理的关键污染物。所提议的用于计算风险商数的基准值基于健康,系统定义,科学合理,易于应用且易于解释。所提议的方法基于利用毒性信息推导未受监管污染物的基于健康的水平,以及对于没有毒性数据的未受监管污染物设定“毒理学关注阈值”。这种方法的应用将有助于政策制定者制定关于再生水中未受监管化学品的指南。