Ramirez Marc S, Ragan Dustin K, Kundra Vikas, Bankson James A
Department of Imaging Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030-4009, USA.
Magn Reson Med. 2007 Sep;58(3):610-5. doi: 10.1002/mrm.21348.
Dynamic contrast-enhanced (DCE-) MRI is often used to evaluate the response to experimental antiangiogenic therapies in small animal models of cancer. Unfortunately, DCE-MRI studies often require a substantial investment of both time and money to achieve the desired level of statistical significance. Multiple-mouse MRI has previously been used to improve imaging efficiency, but its feasibility for DCE-MRI has not been investigated. The purpose of this work was to determine if multiple-mouse DCE-MRI is feasible when using gadolinium-based contrast agents with a low molecular weight. A population of tumor-bearing mice was scanned using two four-element arrays and a single-coil configuration on a 4.7T, 40 cm bore Bruker Biospec MRI scanner. Pharmacokinetic parameters were calculated and compared to determine if a significant difference between methodologies existed. With both four-animal imaging configurations, animal throughput accelerations of just less than three were achieved and quantitative data were not significantly different than from single-animal acquisitions.
动态对比增强（DCE-）磁共振成像常用于评估癌症小动物模型中实验性抗血管生成疗法的疗效。不幸的是，DCE-MRI研究通常需要投入大量的时间和资金才能达到所需的统计学显著性水平。此前已采用多只小鼠MRI来提高成像效率，但尚未研究其在DCE-MRI中的可行性。本研究的目的是确定在使用低分子量钆基造影剂时，多只小鼠DCE-MRI是否可行。在一台4.7T、40cm孔径的布鲁克Biospec MRI扫描仪上，使用两个四元素阵列和单线圈配置对一群荷瘤小鼠进行扫描。计算并比较药代动力学参数，以确定不同方法之间是否存在显著差异。在两种四只动物的成像配置中，动物通量加速均略低于三倍，定量数据与单只动物采集的数据无显著差异。
