Department of Imaging Physics, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030-4009, USA.
Magn Reson Med. 2010 Mar;63(3):803-10. doi: 10.1002/mrm.22236.
Compared to traditional single-animal imaging methods, multiple-mouse MRI has been shown to dramatically improve imaging throughput and reduce the potentially prohibitive cost for instrument access. To date, up to a single radiofrequency coil has been dedicated to each animal being simultaneously scanned, thus limiting the sensitivity, flexibility, and ultimate throughput. The purpose of this study was to investigate the feasibility of multiple-mouse MRI with a phased-array coil dedicated to each animal. A dual-mouse imaging system, consisting of a pair of two-element phased-array coils, was developed and used to achieve acceleration factors greater than the number of animals scanned at once. By simultaneously scanning two mice with a retrospectively gated cardiac cine MRI sequence, a 3-fold acceleration was achieved with signal-to-noise ratio in the heart that is equivalent to that achieved with an unaccelerated scan using a commercial mouse birdcage coil.
与传统的单只动物成像方法相比，多只老鼠 MRI 已被证明可以显著提高成像通量，并降低仪器访问的潜在昂贵成本。迄今为止，多达一个射频线圈被专门用于同时扫描的每只动物，从而限制了灵敏度、灵活性和最终的吞吐量。本研究的目的是研究专用相控阵线圈的多只老鼠 MRI 的可行性。开发了一种双鼠成像系统，由一对双元件相控阵线圈组成，用于实现大于一次扫描动物数量的加速因子。通过使用回顾性门控心脏电影 MRI 序列同时扫描两只老鼠，实现了 3 倍的加速，心脏的信噪比与使用商业老鼠鸟笼线圈进行的未加速扫描相当。
