Kenfield Stacey A, Chang Stephanie T, Chan June M
University of CA San Francisco, 1600 Divisadero St., San Francisco, CA 94143-1695, USA.
Curr Treat Options Oncol. 2007 Jun;8(3):173-96. doi: 10.1007/s11864-007-0034-0.
Active Surveillance (AS) is a viable, alternative option for patients who are diagnosed with favorable prognostic risk prostate cancer, and who are willing to undergo conservative, expectant management until treatment is warranted due to progression of the disease. Lifestyle interventions in patients who choose AS is an emerging area of research, and several studies are ongoing with results pending. New intervention studies will increase our knowledge of the etiology of prostate cancer and help determine whether dietary factors can influence prostate carcinogenesis after diagnosis in AS patients. The considerable amount of epidemiologic and experimental data relating components of the diet with prostate cancer risk suggest that diet or lifestyle interventions could potentially lengthen the period of active surveillance before treatment management is necessary, and further research is warranted to study the direct effects on secondary clinical outcomes.
主动监测(AS)对于被诊断为预后风险良好的前列腺癌患者且愿意接受保守的观察等待管理直至因疾病进展而需要治疗的患者来说是一种可行的替代选择。对于选择主动监测的患者,生活方式干预是一个新兴的研究领域,目前有几项研究正在进行,结果尚未可知。新的干预研究将增加我们对前列腺癌病因的了解,并有助于确定饮食因素是否会影响主动监测患者诊断后的前列腺癌发生。大量将饮食成分与前列腺癌风险相关联的流行病学和实验数据表明,饮食或生活方式干预可能会延长治疗前主动监测的时间,因此有必要进行进一步研究以探讨其对次要临床结局的直接影响。