Wang Kewei, Wu Guosheng, Li Jinping, Song Wentao
Wuxi Medical School, Jiangnan University, Wuxi, Jiangsu, 214122, People's Republic of China.
Nanchang Center for Disease Control and Prevention, 833 Lijing Road, Nanchang, Jiangxi, People's Republic of China.
BMC Cancer. 2016 Aug 23;16(1):674. doi: 10.1186/s12885-016-2722-2.
Vitamin D receptor (VDR) gene polymorphisms affect the risk of prostate cancer. However, studies investigating the relationship between VDR gene polymorphisms (Cdx2 and ApaI) and prostate cancer risk are equivocal. Therefore, we conducted a meta-analysis of all the studies to review the evidence available.
A comprehensive search of PubMed, EMBASE, and ISI Web of Science for studies published until September 2015 was conducted. Odds ratios (ORs) and 95 % confidence intervals (CIs) were analyzed to determine the association between VDR Cdx2 and ApaI polymorphisms, and prostate cancer risk.
The meta-analysis included 10 studies involving 4979 cases and 4380 controls to analyze the VDR Cdx2 polymorphism. An additional 11 studies involving 2837 cases and 2884 controls were analyzed for the VDR ApaI polymorphism. Evidence failed to support the role of VDR Cdx2 and ApaI polymorphisms in prostate cancer. For Cdx2, the pooled OR was 1.11 (95 % CI = 0.93-1.33) for AA vs. GG genotypes, 0.97 (95 % CI = 0.88-1.06) for GA vs. AA genotypes, 0.99 (95 % CI = 0.91-1.08) for AA + GA vs. GG, and 1.12 (95 % CI = 0.95-1.31) for AA vs. GA + GG. No significant relationship was observed in any subgroup analysis based on ethnicity, controls, and Hardy-Weinberg equilibrium (HWE). ORs for the ApaI polymorphism were similar.
VDR Cdx2 and ApaI polymorphisms are not associated with prostate cancer. Additional evidence is required to confirm this conclusion.
维生素D受体（VDR）基因多态性会影响前列腺癌风险。然而，关于VDR基因多态性（Cdx2和ApaI）与前列腺癌风险之间关系的研究结果并不明确。因此，我们对所有研究进行了一项荟萃分析，以审视现有证据。
全面检索了PubMed、EMBASE和ISI科学网，查找截至2015年9月发表的研究。分析比值比（OR）和95%置信区间（CI），以确定VDR Cdx2和ApaI基因多态性与前列腺癌风险之间的关联。
荟萃分析纳入了10项研究，共4979例病例和4380例对照，用于分析VDR Cdx2基因多态性。另外11项研究共2837例病例和2884例对照用于分析VDR ApaI基因多态性。证据不支持VDR Cdx2和ApaI基因多态性在前列腺癌中的作用。对于Cdx2，AA与GG基因型相比，合并OR为1.11（95%CI = 0.93 - 1.33）；GA与AA基因型相比，为0.97（95%CI = 0.88 - 1.06）；AA + GA与GG相比，为0.99（95%CI = 0.91 - 1.08）；AA与GA + GG相比，为1.12（95%CI = 0.95 - 1.31）。在基于种族、对照和哈迪-温伯格平衡（HWE）的任何亚组分析中均未观察到显著关系。ApaI基因多态性的OR值相似。
VDR Cdx2和ApaI基因多态性与前列腺癌无关。需要更多证据来证实这一结论。
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