类风湿关节炎中的激活型和抑制型Fcγ受体：从治疗到靶向治疗
Activating and inhibitory Fc gamma receptors in rheumatoid arthritis: from treatment to targeted therapies.
作者信息
van Roon Joel A G
出版信息
Arthritis Res Ther. 2007;9(4):106. doi: 10.1186/ar2224.
Abstract
Fc gamma receptors (Fc gammaRs) bind the constant Fc region of IgG molecules. IgG/antigen-containing immune complexes elicit a variety of effector functions in cells that express activating Fc gammaRs. Because activating Fc gammaRs are present on cells from the innate immune system, such as dendritic cells, monocytes/macrophages and granulocytes, these IgG receptors form a crucial link between the innate and the acquired immune systems. Recently, the ability to detect the inhibitory Fc gammaRIIb on cells has indicated an imbalance between activating and inhibitory Fc gammaRs in rheumatoid arthritis. This progress offers an opportunity to study modulation of Fc gammaR balance and could stimulate development of Fc gammaR-directed immunotherapy.
摘要
Fcγ受体（FcγRs）可结合IgG分子的恒定Fc区域。含IgG/抗原的免疫复合物在表达活化性FcγRs的细胞中引发多种效应功能。由于活化性FcγRs存在于天然免疫系统的细胞上，如树突状细胞、单核细胞/巨噬细胞和粒细胞，这些IgG受体在天然免疫系统和获得性免疫系统之间形成了关键联系。最近，在细胞上检测到抑制性FcγRIIb的能力表明类风湿性关节炎中活化性和抑制性FcγRs之间存在失衡。这一进展为研究FcγR平衡的调节提供了机会，并可能刺激针对FcγR的免疫疗法的发展。
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