De Marino V, Pisanti N, Capone D
Department of Human Communicative Sciences, II School of Medicine, University of Naples, Italy.
Acta Neurol (Napoli). 1991 Oct;13(5):410-7.
Female aged rats treated with nimodipine, a calcium-blocker dihydropyridine derivative, were submitted to a psychological-stress situation. Nimodipine at the doses of 3 and 6 mg/Kg antagonized the stress-related body-weight decrease and lethality. These findings seem to validate the role of Ca-mediated mechanisms in the physiopathology of stress and the protective effects of the Ca-blockers in the stress-related illnesses.
用钙通道阻滞剂二氢吡啶衍生物尼莫地平治疗的老年雌性大鼠，被置于心理应激状态。3毫克/千克和6毫克/千克剂量的尼莫地平可对抗与应激相关的体重下降和致死率。这些发现似乎证实了钙介导机制在应激生理病理学中的作用以及钙通道阻滞剂对应激相关疾病的保护作用。
