张力蛋白：细胞迁移中的新开关。
Tensins: a new switch in cell migration.
作者信息
Mouneimne Ghassan, Brugge Joan S
机构信息
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
出版信息
Dev Cell. 2007 Sep;13(3):317-9. doi: 10.1016/j.devcel.2007.08.010.
PMID:17765673
Abstract
Epidermal Growth Factor (EGF) is an important regulator of normal epithelial and carcinoma cell migration. The mechanism by which EGF induces cell migration is not fully understood. A recent report in Nature Cell Biology (Katz et al., 2007) demonstrates that EGF regulates migration through a switch in the expression of two tensin isoforms, weakening the association of beta1 integrin with the actin cytoskeleton in focal adhesions.
摘要
表皮生长因子（EGF）是正常上皮细胞和癌细胞迁移的重要调节因子。EGF诱导细胞迁移的机制尚未完全明确。《自然细胞生物学》杂志最近发表的一篇报告（Katz等人，2007年）表明，EGF通过两种张力蛋白异构体表达的转换来调节迁移，从而削弱β1整合素与粘着斑中肌动蛋白细胞骨架的结合。
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