Pearson Chad G, Culver Brady P, Winey Mark
MCD Biology, University of Colorado, Boulder, CO 80309, USA.
Dev Cell. 2007 Sep;13(3):319-21. doi: 10.1016/j.devcel.2007.08.007.
Cilia formation in mammalian cells requires basal bodies that are either derived from centrioles that transition from their cytoplasmic role in centrosome organization or that form en masse in multiciliated cells. Several recent studies have begun to uncover the links between centriole duplication and their transformation to basal bodies.
哺乳动物细胞中的纤毛形成需要基体,这些基体要么源自从其在中心体组织中的细胞质作用转变而来的中心粒,要么在多纤毛细胞中大量形成。最近的几项研究已开始揭示中心粒复制与其向基体转变之间的联系。