Bettencourt-Dias Mónica, Carvalho-Santos Zita
Cell Cycle Regulation Lab, Instituto Gulbenkian de Ciência, Rua da Quinta Grande, 6, P-2780-156 Oeiras, Portugal.
Trends Cell Biol. 2008 Jan;18(1):8-11. doi: 10.1016/j.tcb.2007.11.002.
Centrioles lead an important double life: they can give rise to the centrosome or convert to basal bodies and template cilia. Little is known about the control of centriole fate. Spektor and colleagues have now identified a centriolar complex, composed of CP110 and CEP97, which inhibits centriole to basal body conversion, preventing cilia formation. This work paves the way to understanding centriole and cilia biogenesis, which are two processes misregulated in human diseases, such as cancer and polycystic kidney disease.
它们能够产生中心体，或者转变为基体并作为纤毛的模板。目前对于中心粒命运的调控了解甚少。斯佩克特及其同事现已鉴定出一种由CP110和CEP97组成的中心粒复合体，该复合体可抑制中心粒向基体的转变，从而阻止纤毛形成。这项工作为理解中心粒和纤毛的生物发生铺平了道路，而这两个过程在诸如癌症和多囊肾病等人类疾病中出现了调控异常。
