Hoekert Marjolijn, Kahn René S, Pijnenborg Marieke, Aleman André
BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, The Netherlands.
Schizophr Res. 2007 Nov;96(1-3):135-45. doi: 10.1016/j.schres.2007.07.023. Epub 2007 Sep 4.
Deficits in emotion processing may be one of the most pervasive disturbances in schizophrenia that may contribute to social isolation. In this report we focus on vocal emotion processing. This function bears upon two corner stones of social functioning, language and emotion, which have both been found to be impaired in schizophrenia.
We used meta-analysis to integrate findings of studies published between 1980 and June 2007 on perception of emotional prosody in schizophrenia. 17 studies provided sufficient information to be included. A mean weighted effect size was computed in the random effects model. Publication bias was tested using funnel plots and fail-safe number of studies. Seven studies were included in an analysis on the expression (i.e. production) of emotional prosody in schizophrenia.
A significant and stable mean weighted effect size was found for the perception of emotional prosody, d=-1.24, 95% CI=-1.55 to -0.93. The effect was also found in the early stages of the illness. Expression of emotional prosody was also significantly impaired, d=-1.11, 95% CI=-1.78 to -0.43.
Results indicate that individuals with schizophrenia are impaired in the perception and expression of emotional prosody, with a large effect size. As a growing body of evidence shows that impaired social cognition in schizophrenia may be an important predictor of social outcome, training programs that aim at the recognition of emotional prosody should be developed.
情绪加工缺陷可能是精神分裂症中最普遍的障碍之一，可能导致社交孤立。在本报告中，我们聚焦于言语情绪加工。该功能与社交功能的两个基石——语言和情绪相关，而这两者在精神分裂症中均被发现存在受损情况。
我们采用荟萃分析来整合1980年至2007年6月间发表的关于精神分裂症患者对情绪韵律感知的研究结果。17项研究提供了足够信息得以纳入分析。在随机效应模型中计算平均加权效应量。使用漏斗图和研究的失效安全数来检验发表偏倚。七项研究被纳入对精神分裂症患者情绪韵律表达（即产生）的分析。
在情绪韵律感知方面发现了显著且稳定的平均加权效应量，d = -1.24，95%置信区间 = -1.55至-0.93。在疾病早期也发现了该效应。情绪韵律表达也显著受损，d = -1.11，95%置信区间 = -1.78至-0.43。
结果表明，精神分裂症患者在情绪韵律的感知和表达方面存在受损，效应量较大。鉴于越来越多的证据表明精神分裂症患者的社会认知受损可能是社会结局的重要预测因素，应制定旨在识别情绪韵律的培训项目。
