Kirn-Safran Catherine B, D'Souza Sonia S, Carson Daniel D
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
Semin Cell Dev Biol. 2008 Apr;19(2):187-93. doi: 10.1016/j.semcdb.2007.07.013. Epub 2007 Jul 31.
Complex interactions occur among embryonic, placental and maternal tissues during embryo implantation. Many of these interactions are controlled by growth factors, extracellular matrix and cell surface components that share the ability to bind heparan sulfate (HS) polysaccharides. HS is carried by several classes of cell surface and secreted proteins called HS proteoglycan that are expressed in restricted patterns during implantation and placentation. This review will discuss the expression of HS proteoglycans and various HS binding growth factors as well as extracellular matrix components and HS-modifying enzymes that can release HS-bound proteins in the context of implantation and placentation.
在胚胎植入过程中,胚胎、胎盘和母体组织之间会发生复杂的相互作用。其中许多相互作用受生长因子、细胞外基质和细胞表面成分控制,这些成分都具有结合硫酸乙酰肝素(HS)多糖的能力。HS由几类细胞表面和分泌蛋白携带,这些蛋白称为HS蛋白聚糖,在植入和胎盘形成过程中以受限模式表达。本综述将讨论HS蛋白聚糖和各种HS结合生长因子的表达,以及细胞外基质成分和HS修饰酶,这些酶可在植入和胎盘形成的背景下释放与HS结合的蛋白。