Yin Lu, Wang Qiang, Zhang Qizhi, Jiang Huabei
J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, Florida 32611, USA.
Opt Lett. 2007 Sep 1;32(17):2556-8. doi: 10.1364/ol.32.002556.
We present a new method that can provide high resolution images of absolute optical absorption coefficient in heterogeneous turbid media. In this method, acoustic measurements in conventional photoacoustic tomography are combined with diffusing light measurements to separate the product of absorption coefficient and optical fluence or photon density. We validate this method using a series of tissuelike phantom experiments. The experimental results show that targets as small as 0.5 mm in diameter with optical absorption contrasts as low as 1.5 relative to a 50 mm diameter scattering background medium can be clearly detected.
我们提出了一种新方法,该方法能够提供非均匀浑浊介质中绝对光吸收系数的高分辨率图像。在这种方法中,传统光声层析成像中的声学测量与漫射光测量相结合,以分离吸收系数与光通量或光子密度的乘积。我们通过一系列类似组织的体模实验验证了该方法。实验结果表明,相对于直径为50mm的散射背景介质,直径小至0.5mm且光吸收对比度低至1.5的目标能够被清晰检测到。