促黑素皮质素4型受体激动剂：关于4-烷基哌啶核心的构效关系
Melanocortin subtype 4 receptor agonists: structure-activity relationships about the 4-alkyl piperidine core.
作者信息
Sebhat Iyassu K, Lai Yingjie, Barakat Khaled, Ye Zhixiong, Tang Rui, Kalyani Rubana N, Vongs Aurawan, Macneil Tanya, Weinberg David H, Cabello M Angeles, Maroto Marta, Teran Ana, Fong Tung M, Van der Ploeg Lex H T, Patchett Arthur A, Nargund Ravi P
机构信息
Department of Medicinal Chemistry, Merck & Co., Inc, PO Box, 2000, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2007 Oct 15;17(20):5720-3. doi: 10.1016/j.bmcl.2006.11.084. Epub 2006 Dec 3.
PMID:17768046
Abstract
SAR about the piperidine core in a series of MC4R agonists is described. A number of alkyl substituents that furnish compounds with good affinity and functional potency are reported.
摘要
描述了一系列MC4R激动剂中哌啶核心的构效关系。报道了一些能提供具有良好亲和力和功能效力化合物的烷基取代基。
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