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Use of bortezomib in the management of chronic graft-versus-host disease among multiple myeloma patients relapsing after allogeneic transplantation.

作者信息

Mateos-Mazon Juan, Pérez-Simón José-Antonio, Lopez Olga, Hernández Emiliano, Etxebarria Jaime, San Miguel Jésus F

出版信息

Haematologica. 2007 Sep;92(9):1295-6. doi: 10.3324/haematol.10820.

DOI:10.3324/haematol.10820
PMID:17768136
Abstract

We report on the use of bortezomib for the management of chronic graft versus host disease (cGVHD) among 8 multiple myeloma (MM) patients who relapsed after reduced-intensity conditioning (RIC) allogeneic transplantation. Five patients (62%) responded to bortezomib demonstrating anti-myeloma effect. Four patients had active cGVHD, including 3 patients with severe punctate keratopathy, at the time of bortezomib administration. All showed an improvement in their condition. This is the first report showing that bortezomib may be useful in the management of cGVHD and related ocular involvement.

摘要

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