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减少盐的摄入量会让你更长寿吗?

Does reducing your salt intake make you live longer?

作者信息

Walker Jay, MacKenzie Alastair David, Dunning Joel

机构信息

Department of Cardiothoracic Surgery, James Cook University Hospital, Middlesbrough, UK.

出版信息

Interact Cardiovasc Thorac Surg. 2007 Dec;6(6):793-8. doi: 10.1510/icvts.2007.165415. Epub 2007 Sep 2.

Abstract

A best evidence topic in cardiothoracic surgery was written according to a structured protocol. The question addressed was whether restricting dietary salt intake would provide protection from adverse cardiovascular events or mortality. Using the reported search, 462 papers were identified of which 14 papers represented the best evidence on the subject. The author, journal, date and country of publication, patient group studied, study type, relevant outcomes, results and weaknesses were tabulated. We conclude that restricting sodium intake to levels below 6 g per day as most international guidelines such as those of the AHA, the US Dietary Guideline Committee and the Scientific Advisory Committee on Nutrition recommend, clearly reduces blood pressure and in turn may reduce the need for antihypertensives by as much as 30%. However, the ability of dietary sodium restriction to reduce the incidence of cardiovascular events is more controversial due to the lack of adequately powered randomised trials or observational studies conducted with sufficient rigour. Some of the largest studies such as NHANES and TOHP, which do demonstrate a significant benefit, report a 20-30% relative reduction in adverse events which, due to the low rate of these events in the studies equates to an absolute risk reduction over 10-20 years in the region of 2-3% for protection from adverse cardiovascular events from sodium dietary restriction.

摘要

根据结构化方案撰写了一篇心胸外科的最佳证据主题文章。探讨的问题是限制饮食中的盐摄入量是否能预防不良心血管事件或降低死亡率。通过报告的检索,共识别出462篇论文,其中14篇论文代表了该主题的最佳证据。对作者、期刊、出版日期和国家、所研究的患者群体、研究类型、相关结局、结果及不足之处进行了列表整理。我们得出结论,按照美国心脏协会(AHA)、美国膳食指南委员会以及营养科学咨询委员会等大多数国际指南的建议,将钠摄入量限制在每天6克以下,可显著降低血压,进而可能使抗高血压药物的需求减少多达30%。然而,由于缺乏足够有力的随机试验或严谨的观察性研究,饮食中限制钠摄入对降低心血管事件发生率的作用更具争议性。一些规模较大的研究,如美国国家健康与营养检查调查(NHANES)和高血压预防试验(TOHP),虽确实显示出显著益处,但报告的不良事件相对减少20 - 30%,鉴于研究中这些事件发生率较低,这相当于在10 - 20年期间,通过限制钠饮食预防不良心血管事件的绝对风险降低约2 - 3%。

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