Torp S H, Helseth E, Ryan L, Stølan S, Dalen A, Unsgaard G
Institute of Cancer Research, University of Trondheim, Norway.
Anticancer Res. 1991 Nov-Dec;11(6):2095-8.
Biopsy specimens of 19 human gliomas (10 glioblastomas, 2 anaplastic astrocytomas, 4 astrocytomas, one mixed glioma, one oligodendroglioma and one ependymoma) were examined for amplification of tumour-related genes located on chromosome 7: the proto-oncogene c-erb-B1 (encoding the epidermal growth factor receptor (EGFR], the proto-oncogene c-met, the platelet-derived growth factor A-chain gene, and the plasminogen activator inhibitor type-1 gene. Gene amplification was observed in 6 glioblastomas, and the EGFR gene was the only chromosome-7-gene examined that was amplified. The selective EGFR gene amplification in human glioblastomas suggests its potential role in the progression of some of these tumours.
对19例人类胶质瘤（10例胶质母细胞瘤、2例间变性星形细胞瘤、4例星形细胞瘤、1例混合性胶质瘤、1例少突胶质细胞瘤和1例室管膜瘤）的活检标本进行检测，以确定位于7号染色体上的肿瘤相关基因的扩增情况：原癌基因c-erb-B1（编码表皮生长因子受体[EGFR]）、原癌基因c-met、血小板衍生生长因子A链基因和纤溶酶原激活物抑制剂1型基因。在6例胶质母细胞瘤中观察到基因扩增，EGFR基因是检测的唯一扩增的7号染色体基因。人类胶质母细胞瘤中EGFR基因的选择性扩增提示其在某些此类肿瘤进展中的潜在作用。
