恶性疟原虫感染对马拉维儿童血浆α1-酸性糖蛋白浓度及奎宁结合的影响。
Effect of Plasmodium falciparum malaria infection on the plasma concentration of alpha 1-acid glycoprotein and the binding of quinine in Malawian children.
作者信息
Mansor S M, Molyneux M E, Taylor T E, Ward S A, Wirima J J, Edwards G
机构信息
Department of Pharmacology and Therapeutics, University of Liverpool.
出版信息
Br J Clin Pharmacol. 1991 Sep;32(3):317-21. doi: 10.1111/j.1365-2125.1991.tb03905.x.
Abstract
- We have measured plasma concentrations of alpha 1-acid glycoprotein (AGP) in 18 healthy children and 85 children with falciparum malaria in Malawi. In addition, we determined the degree of protein binding of quinine (QN) in the plasma of 52 of the patients and each of the healthy controls. 2. The mean plasma AGP concentration was higher in patients than in controls (P less than 0.0001) and remained elevated 3 weeks after complete resolution of malaria infection. 3. The mean unbound QN fraction was significantly less (P less than 0.00001) in patients with malaria (0.128 +/- 0.037) than in controls (0.193 +/- 0.051) and significantly higher (P = 0.02) in convalescence (0.153 +/- 0.067) than during acute illness. 4. There were highly significant negative correlations between plasma AGP concentration and the free QN fraction in spiked plasma samples (r = -0.534, P less than 0.0001, n = 93) and in clinical samples (r = -0.484, P less than 0.00001, n = 225). There was a significant positive correlation between plasma concentrations of AGP and another acute phase reactant, C reactive protein (P less than 0.001).
摘要
- 我们测定了马拉维18名健康儿童和85名恶性疟患儿血浆中α1 -酸性糖蛋白（AGP）的浓度。此外，我们还测定了52例患者及每例健康对照者血浆中奎宁（QN）的蛋白结合程度。2. 患者血浆AGP平均浓度高于对照组（P＜0.0001），且在疟疾感染完全消退3周后仍维持在较高水平。3. 疟疾患者的平均游离QN分数（0.128±0.037）显著低于对照组（0.193±0.051）（P＜0.00001），且恢复期（0.153±0.067）显著高于急性期（P = 0.02）。4. 在加标血浆样本（r = -0.534，P＜0.0001，n = 93）和临床样本（r = -0.484，P＜0.00001，n = 225）中，血浆AGP浓度与游离QN分数之间存在高度显著的负相关。AGP血浆浓度与另一种急性期反应物C反应蛋白之间存在显著正相关（P＜0.001）。
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