Spillane J D, Urich H
J Neurol Neurosurg Psychiatry. 1976 Feb;39(2):105-13. doi: 10.1136/jnnp.39.2.105.
Two cases are reported of progressive trigeminal neutopathy with nasal ulceration. One patient developed signs of spinal cord involvement 15 years after the onset of trigeminal symptoms and died after a total course of 21 years. Necropsy revealed an unusual trigeminospinal system degeneration with deposition of amyloid-like substances in the affected structures. The other patient is alive eight years after the onset of symptoms, the only indication of a lesion outside the trigeminal nerve being a patch of numbness in one leg.
报告了两例伴有鼻溃疡的进行性三叉神经病变。一名患者在三叉神经症状出现15年后出现脊髓受累迹象，并在病程21年后死亡。尸检显示三叉神经脊髓系统出现异常变性，在受累结构中有淀粉样物质沉积。另一名患者在症状出现8年后仍然存活，唯一显示三叉神经以外有病变的迹象是一条腿上有一片麻木区域。
