Douglass E C, Rowe S T, Valentine M, Parham D M, Berkow R, Bowman W P, Maurer H M
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101.
Genes Chromosomes Cancer. 1991 Nov;3(6):480-2. doi: 10.1002/gcc.2870030611.
In three cases of alveolar rhabdomyosarcoma with variant translocations, two tumors contained an identical translocation, t(1;13)(p36.1;q14); the third tumor contained a t(8;13)(p21;q14). All three patients were 2 years old, markedly younger than the median age for patients with t(2;13)-positive alveolar rhabdomyosarcoma. The alteration of genetic material on chromosome 13 may be of primary importance in the development of alveolar rhabdomyosarcoma.
