Lovett J V, McGregor D B
Department of Surgery, University of Nevada School of Medicine, Reno 89520.
J Invest Surg. 1991;4(4):431-5. doi: 10.3109/08941939109141173.
Pentagastrin is trophic to the colon but the physiologic effects of pentagastrin are incompletely known. We compared in vivo potassium (K+) absorption from the colons of pentagastrin-treated (PG, n = 13), sham (S, n = 12), and control (C, n = 3) Sprague-Dawley rats during continuous intraluminal K+ perfusion. Preoperative intraperitoneal injections were administered to PG (pentagastrin 0.25 mg/kg in 2 mL 0.9% NaCl q 12 h x 48 h) and S (2 mL 0.9% NaCl q 12 h x 48 h). Under xylazine anesthesia, cannulae were placed in the cecum, rectum, and femoral artery of each rat. Intraluminal perfusion was performed for 2 h at 30 mL/min with 40 meq/L KCl in 0.9% NaCl (PG and S) or 0.9% NaCl (C). We monitored serum sodium (Na+) and K+ every 15 min, and the affluent and effluent Na+ and K+ every 30 min. At each interval past 60 min, we observed higher serum K+ in PG compared with S and C (P less than .002) and higher K+ in S compared with C (P less than .05). No changes in serum Na+ occurred. We conclude that pentagastrin stimulates potassium absorption from the colon.
五肽胃泌素对结肠具有营养作用，但其生理效应尚未完全明确。我们比较了经五肽胃泌素处理（PG组，n = 13）、假手术（S组，n = 12）和对照（C组，n = 3）的Sprague-Dawley大鼠在持续肠腔内钾离子（K⁺）灌注期间结肠对钾离子的体内吸收情况。术前对PG组（每12小时腹腔注射0.25 mg/kg五肽胃泌素溶于2 mL 0.9%氯化钠溶液，共48小时）和S组（每12小时腹腔注射2 mL 0.9%氯化钠溶液，共48小时）进行腹腔注射。在赛拉嗪麻醉下，将插管分别置于每只大鼠的盲肠、直肠和股动脉。以30 mL/min的速度用0.9%氯化钠溶液中的40 meq/L氯化钾（PG组和S组）或0.9%氯化钠溶液（C组）进行肠腔内灌注2小时。我们每15分钟监测血清钠（Na⁺）和钾（K⁺），每30分钟监测流入和流出的Na⁺和K⁺。在60分钟后的每个时间间隔，我们观察到PG组的血清K⁺高于S组和C组（P < 0.002），S组的K⁺高于C组（P < 0.05）。血清Na⁺未发生变化。我们得出结论，五肽胃泌素可刺激结肠对钾的吸收。
