促肾上腺皮质激素对肾上腺皮质的反应（作者译）

[Adrenocortical responses to ACTH (author's transl)].

作者信息

Tremblay R R, Normand M, Fortier C

出版信息

J Physiol (Paris). 1976 Jan;70(6):709-15.

Abstract

To characterize by a mathematical model the dynamics of adrenocortical responses to ACTH, the concentration of plasma corticosterone was measured following a series of injections and perfusions of ACTH to dexamethasone-treated male rats. A similar slope was observed during the rise of plasma corticosterone following graded pulse inputs, and the steady-state corticosterone secretion rate was shown to increase proportionally to the perfusion rate of ACTH up to saturation corresponding to maximal secretion. The data will be used, concurrently with our model of the dynamics of plasma cortiscosterone, for the identification of a mathematical model of the adrenocortical response to ACTH.

摘要

为了通过数学模型描述肾上腺皮质对促肾上腺皮质激素（ACTH）反应的动力学，在对用 dexamethasone 处理的雄性大鼠进行一系列 ACTH 注射和灌注后，测量了血浆皮质酮的浓度。在分级脉冲输入后血浆皮质酮升高期间观察到类似的斜率，并且稳态皮质酮分泌率显示与 ACTH 的灌注率成比例增加，直至达到对应于最大分泌的饱和度。这些数据将与我们的血浆皮质酮动力学模型一起用于确定肾上腺皮质对 ACTH 反应的数学模型。