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[实验性烧伤损伤中交感神经节肾上腺素能和胆碱能结构的病理形态学]

[Pathomorphology of adrenergic and cholinergic structures of sympathetic nerve ganglia in experimental burn injuries].

作者信息

Isaev I M

出版信息

Biull Eksp Biol Med. 1991 Dec;112(12):643-6.

PMID:1777640
Abstract

Changes in adreno- and cholinergic structures of sympathetic nerve ganglia (superior cervical, stellate, and splanchnic ganglia of the solar plexus) were studied in 15 male white rats aged 5-7 months, b. m. 200-250 g, 3, 7, and 11 days after burn injury (Stages IIIA, IIIB, involving 20-25% of body surface) and in 5 reference animals. The sections were treated in 2% glyoxylic acid solution and by the Karnovsky-Roots technique. Reduced catecholamine concentrations were revealed in sympathetic nerve ganglia neurons in the early periods after burn injury; the mediator reserves are recovered to a certain measure in later periods after thermal injury. The detected shifts in the sympathetic nerve ganglia neurons correlate with the detected shifts in the cardiovascular system.

摘要

对15只5 - 7个月大、体重200 - 250克的雄性白色大鼠,在烧伤后3天、7天和11天(ⅢA期、ⅢB期,体表面积烧伤20 - 25%)以及5只对照动物中,研究了交感神经节(颈上神经节、星状神经节和太阳神经丛的内脏神经节)的肾上腺素能和胆碱能结构变化。切片用2%乙醛酸溶液处理并采用卡诺夫斯基 - 鲁茨技术。在烧伤后的早期,交感神经节神经元中儿茶酚胺浓度降低;热损伤后期介质储备有一定程度的恢复。在交感神经节神经元中检测到的变化与在心血管系统中检测到的变化相关。

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