Leonard G
Montreal Neurological Institute, Quebec, Canada.
Can J Neurol Sci. 1991 Nov;18(4 Suppl):593-7. doi: 10.1017/s0317167100032777.
A retrospective study of 383 patients who had undergone either left or right anterior temporal lobectomy (varying with respect to the amount of hippocampus excised) revealed that there were no significant differences in surgical outcome between those patients having a large and those patients having a small hippocampal removal. Although left temporal-lobe excisions were significantly smaller than right temporal-lobe excisions, both medially and laterally, patients with left temporal-lobe removals had an overall better surgical outcome. Patients in the successful surgical-outcome group did better than the unsuccessful surgical-outcome group on a variety of cognitive measures, including tests of intelligence, delayed verbal memory, and verbal fluency. The results suggest that, for many patients with medically intractable epilepsy, an anterior temporal lobectomy including the amygdala may suffice to reduce their seizure frequency.
一项对383例行左或右前颞叶切除术（海马切除量不同）患者的回顾性研究显示，海马切除量大的患者与海马切除量小的患者在手术结果上无显著差异。尽管左侧颞叶切除术在内侧和外侧均明显小于右侧颞叶切除术，但行左侧颞叶切除术的患者总体手术结果更好。在各种认知测试中，包括智力测试、延迟言语记忆测试和言语流畅性测试，手术结果成功组的患者比手术结果不成功组的患者表现更好。结果表明，对于许多药物难治性癫痫患者，包括杏仁核在内的前颞叶切除术可能足以降低其癫痫发作频率。
