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Studies on antiatherosclerotic agents. Synthesis of 5-substituted derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)-phthalazinone.off.

作者信息

Eguchi Y, Ishikawa M

机构信息

Institute for Medical and Dental Engineering, Tokyo Medical and Dental University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Jul;39(7):1846-8. doi: 10.1248/cpb.39.1846.

DOI:10.1248/cpb.39.1846
PMID:1777938
Abstract

Several 5-substituted derivatives of 7-ethoxycarbonyl-6,8-dimethyl-1(2H)- phthalazinone were prepared by means of nitration, reductive amination, and diazonium decomposition. The substituents introduced included NO2, NH2, F, Cl, CN. Among the derivatives, the fluorine compound was obtained only in poor yield because intramolecular cyclization occurred predominantly.

摘要

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