与肢端肥大症临床综合征相关的垂体肿瘤的临床形态学研究

A clinicomorphological study of pituitary tumors associated with the clinical syndrome of acromegaly.

作者信息

Andreeva M, Georgiev T, Bosadjieva E, Karagiosov L, Karagiosov K, Tomova A, Matrosov P, Kirilov G, Diankov L, Christova T

机构信息

Institute of Endocrinology and Gerontology, Medical Academy, Sofia/Bulgaria.

出版信息

Exp Clin Endocrinol. 1991;98(3):223-7. doi: 10.1055/s-0029-1211121.

DOI:10.1055/s-0029-1211121

PMID:1778242

Abstract

Transsphenoidal adenomectomy was done on 125 acromegalics. A clinicomorphological study was performed on 113 of these patients. The distribution of morphological types of tumors was similar in both sexes. In the total group it was: sparsely granulated GH cell adenomas 52.8%, densely granulated 25.7%, mixed somatotroph and lactotroph adenomas 15.9%, plurihormonal adenomas 1.8%, acidophil stem cell adenomas 2.6%, and oncocytoma 1.8%. The GH plasma level in male patients was significantly higher than in female patients. In both sexes GH secretion was highest in patients with mixed GH and PRL cell adenomas followed by patients with densely granulated GH cell adenomas. Plasma PRL levels were significantly elevated in all males, except for those with densely granulated GH adenomas where prolactinemia was normal. The mean plasma PRL levels were also elevated in females with highest values in mixed somatotroph and lactotroph adenomas. The PRL levels in female patients with densely granulated GH cell adenomas are more elevated than in female patients with sparsely granulated GH cell adenomas.

摘要

对125例肢端肥大症患者实施了经蝶窦腺瘤切除术。对其中113例患者进行了临床形态学研究。肿瘤形态学类型的分布在两性中相似。在整个组中，其分布情况如下：稀疏颗粒型生长激素（GH）细胞腺瘤52.8%，密集颗粒型25.7%，生长激素细胞和催乳素细胞混合腺瘤15.9%，多激素腺瘤1.8%，嗜酸性干细胞腺瘤2.6%，以及嗜酸性细胞瘤1.8%。男性患者的血浆GH水平显著高于女性患者。在两性中，GH和催乳素（PRL）细胞混合腺瘤患者的GH分泌最高，其次是密集颗粒型GH细胞腺瘤患者。除了密集颗粒型GH腺瘤患者催乳素血症正常外，所有男性患者的血浆PRL水平均显著升高。女性患者的平均血浆PRL水平也升高，在生长激素细胞和催乳素细胞混合腺瘤患者中最高。密集颗粒型GH细胞腺瘤女性患者的PRL水平比稀疏颗粒型GH细胞腺瘤女性患者更高。